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doi: 10.1016/j.joca.2015.03.031 132 MooneyRASampsonERLereaJRosierRNZuscikMJ

Although preclinical evidence suggests that GLP-1RAs can cross the blood-brain barrier (BBB), the efficacy of CNS delivery and the precise therapeutic dosage necessary to achieve neuroprotective concentrations in people are unclear

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While most in vivo studies evaluate effects of the classical androgens and E2 in rodents, important limitations of these models are that rodents do not biosynthesise 11-oxygenated androgens, and that SHBG is not found in rodents [84] except in humanised transgenic mice [84, 198, 203]

The FODMaP diet can lead to a significantly lowered intake of fiber from fruits and vegetables, which could lead to micronutrient deficiencies and adversely affect the microbiome